Southampton 1-2 Grimsby: League Two club stun Premier League ...

League Two club Grimsby became shock FA Cup quarter-finalists as they knocked out Premier League side Southampton with a 2-1 win at St Mary's.

Gavan Holohan scored two penalties either side of half-time to give Grimsby a shock two-goal lead after Lyanco and Duje Caleta-Car gave away spot-kicks.

Caleta-Car pulled one back from a corner while substitute Theo Walcott saw an equaliser ruled out by VAR in the final 10 minutes.

Grimsby have now become the first club in FA Cup history to eliminate five teams from a higher division than them in a single campaign and will face another top-flight opposition on the south coast as they were paired with Brighton in round six.

How the teams lined up | Match statsFA Cup fixtures | Get Sky Sports

The League Two side arrived on the south coast seeking to reach the last eight of the cup competition for the first time since 1939 and backed by more than 4,200 boisterous fans waving inflatable fish.

Grimsby faced a Southampton side showing nine alterations from Saturday's damaging 1-0 defeat at Leeds and with more home wins in the cup than the top flight this term.

Saints' much-changed side dominated possession but rarely threatened as they tried to inspire a sparse and subdued home crowd.

Sekou Mara saw an 18th-minute finish disallowed for offside against creator Moussa Djenepo and later scuffed a tame shot at Town goalkeeper Max Crocombe, while Mislav Orsic curled narrowly wide and Carlos Alcaraz fluffed a diving header attempt.

A largely forgettable first half of few chances burst into life just before the break as Grimsby benefited from a lengthy VAR check to edge ahead when Saints defender Lyanco inexplicably handled Joshua Emmanuel's cross as he misjudged a header under little pressure.

Referee Thomas Bramall watched replays on the pitchside monitor and, around six minutes after the initial incident, Holohan coolly stepped up to send Alex McCarthy the wrong way from the spot and spark mayhem among the travelling hordes.

Saints boss Ruben Selles would have been desperate for a swift response from his side but his half-time team talk was quickly undermined by a farcical moment of petulance.

After snuffing out the danger, Caleta-Car foolishly slapped Danilo Orsi in the back inside the 18-yard box, prompting match official Bramall to point to the spot for a second time.

Irishman Holohan once again took responsibility, coolly dispatching a rising effort into the left corner beyond the fingertips of McCarthy.

Spaniard Selles responded to the perilous position by introducing captain James Ward-Prowse and Samuel Edozie from the bench.

Ward-Prowse sparked hope of a fightback by delivering an inviting in-swinging corner for the unmarked Caleta-Car to make amends for his earlier error of judgement by volleying home unmarked.

Saints piled forward in search of an equaliser and were almost caught on the counter-attack when John McAtee burst clear from halfway before overrunning the ball at the crucial moment.

Extra-time then looked on the cards when Walcott spun to convert following a quick Ward-Prowse free-kick into the box.

But Paul Hurst's men received a reprieve from Stockley Park, leaving the raucous away end to revel in a memorable evening out ahead of a 240-mile journey home, while Saints were jeered off in shame as attention turns back to their scrap for survival.

Grimsby's Hurst: We're going down in history

Hurst believes Grimsby's players will go down in the history books after reaching the FA Cup quarter-finals

The manager, who guided the club to promotion from the National League through the play-offs last term, revealed there were some stunned faces in the dressing room.

"I'm in shock," Hurst told BBC Radio 5 Live. "I'm so delighted for the owners and the incredible away support.

"I [told the players] we could lose 10-0. I was saying I might have to bring a blindfold. It's always the fear - if a Premier League team turns up, they can blow any League Two side away."

He added of this squad, who travel to Carlisle on Saturday: "They deserve to have maybe more celebrations than what they will get.

"There's quite a bit of the group that enjoyed that experience of winning promotion and getting back in the league. They did enjoy it in the dressing room. Looking around at a few of their faces, they were in shock, probably very tired as well.

"But there were a few songs and a bit of music. I'm just pleased for them. It's a memory for them, for the owners, for the supporters and we go down in history because of the way we've got to the quarter-finals."

Southampton boss Ruben Selles rued the costly moments of madness but refused to blame individuals as he turns his attention back to the top-flight relegation scrap.

"I am very disappointed with the performance and the result," said the Spaniard.

"It's just difficult when you concede those type of penalties. It was not good enough from us. Both penalties were very, very frustrating. We should not allow that to happen."

FA Cup quarter-final draw in full

Man City vs Burnley

Man Utd vs Fulham

Brighton vs Grimsby

Sheffield United vs Blackburn

FA Cup key datesQuarter-finals - Set to be played the weekend of March 18 and 19Semi-finals - Set to be played on the weekend of April 22 and 23Final - Saturday June 3What's next?

Leicester visit Southampton in the Premier League, live on Saturday Night Football; kick-off 5.30pm. Grimsby Town visit Carlisle United in Sky Bet League Two on Saturday; kick-off 3pm.