Matthew Perry allegedly took several doses of ketamine on day of his death

During the time leading up to his passing last year, Matthew Perry instructed his personal assistant, who lived with him, to administer multiple ketamine injections through an IV, as confirmed by the assistant's testimony to authorities.

The performer, who was discovered submerged in a hot tub at his residence in Los Angeles in October, requested his assistant, Kenneth Iwamasa, to administer a dose at 8.30am, as stated in legal documents.

After four hours passed, he was watching a movie at home when he requested Iwamasa for another injection. Only 40 minutes later, Perry instructed him to administer a higher dosage.

"Perry asked Iwamasa for a large injection," the papers reported. Then, Perry told him to prepare the hot tub. After receiving the dose, Iwamasa left to complete errands. When he came back, he found Perry submerged in the water.

A document released by the Los Angeles county medical examiner's office revealed that Perry, who was 54 years old, passed away due to the immediate impact of ketamine. The report also stated that he drowned in the deep end of his pool, which was at a high temperature.

Ketamine is a drug that is commonly used for medical purposes, but some people also use it for pleasure. It is also used to help with depression. The report discovered that Buprenorphine, another type of drug used to help people addicted to heroin, was also a factor in Perry's death.

The capture of five individuals on Thursday in relation to Perry's death, which includes Iwamasa; two physicians, Mark Chavez and Salvador Plasencia; and the drug suppliers Jasveen Sangha, also known as "the Ketamine Queen", and Erik Fleming, has revealed a network of upscale drug distribution within the celebrity community.

Based on a timeline pieced together from police reports, Perry's final days were marked by an increasing hunt for the substance. Prosecutors at the federal level claim that the five individuals facing charges "exploited Mr. Perry's dependence to make money for themselves".

Police officers have stated that Perry started depending more on ketamine and resorted to buying from illegal sellers when a local clinic turned down his request.

The actor's growing reliance on the medication is similar to what happened to singer Michael Jackson, who had begun depending on a semi-legal amount of another anesthetic called propofol.

There have been reports outlining alarming signs that Perry's addiction had reached critical levels: he was discovered unconscious several times and witnessed losing his ability to talk or move after taking drugs.

Based on what Iwamasa said, he was responsible for scheduling Perry's medical appointments and making sure he took his prescribed medications. Iwamasa mentioned that he was referred to Plasencia as a supplier for the medications.

Plasencia had previously talked with the other doctor accused in the case, Chavez, about the potential financial gains they could get from Perry, as stated in legal papers.

"I'm curious how much money this idiot will give us," Plasencia messaged Chavez. Prosecutors claim that Chavez provided 22 vials of ketamine and ketamine lozenges using a fake prescription. Chavez apparently responded with: "Let's see."